Wearable devices are shaping this digital world. It will endow the world's highest intelligent creatures -humans with new attributes such as digitization, Internet of Things (IoT), quantitative sensing and detection. Green and sustainable energy supply for flexible wearable devices is a challenging and crucial research frontier. This project will focus on the cutting-edge power generation approaches, behind which physics of various energy conversion mechanisms. Based on application scenarios in healthcare, industrial inspection, structural monitoring, armed forces and consumer electronics, etc., a system architecture of the wearable flexible system is to be designed and tested. It is expected to make breakthroughs and reshape the digital world by developing all-in-one printable wearable electronics, self-powered self-aware wearable system, hybrid-integrated system on chip for flexible electronics, and IoT-enabled self-contained system towards full life cycle monitoring.